Process for the preparation of a pyridinemethanol compound

Details Process for the preparation of a pyridinemethanol compound Process for the preparation of a pyridinemethanol compound

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01)

Patent

CA 2394439

A pyridinemethanol compound is an important intermediate for a mirtazapine which is useful as an antidepressant. The pyridinemethanol compound is obtained by reducing potassium pyridinecarboxylate represented by the formula (I): (see formula I) with a metal hydride.

Le procédé de l'invention consiste à préparer un composé pyridineméthanol servant en tant qu'intermédiaire principal dans la préparation de la mirtazapine, laquelle constitue un antidépresseur, en faisant réduire un sel de potassium de l'acide pyridinecarboxylique, tel que représenté par la formule (I), avec un hydrure métallique.

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