A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/130
A61K 39/205 (2006.01)
Patent
CA 1271708
ABSTRACT OF THE DISCLOSURE The invention relates to a process for the preparation of a rabies vaccine by multiplication of rabies viruses in animal nerve tissue or poultry embryos, harvesting of the viruses from the nerve tissue or from the heads of the embryos, enriching the viral preparation, inactivating thereof, and preparing a vaccine. In one aspect, the process comprises homogenizing the nerve tissue or embryo heads and harvesting of the viruses therefrom by avoiding the use of a mixer, and thus preventing damage to and fragmentation of the viruses. The nerve tissue, the embryo heads or their contents are comminuted in a manner which preserves cell and viral integrity. The preparation is then treated by separating the complete live viruses which are capable of multiplication from the resulting cell suspension, delipidating by extraction with a water-immiscible organic solvent and then further selectively concentrating the viruses thereof. The invention also relates to a myelin-free rabies vaccine which has been obtained by the process described above from animal were tissue or poultry embryo head tissue containing rabies viruses.
517612
Germanier Rene
Gluck Reinhard
Riches Mckenzie & Herbert Llp
Schweizerisches Serum-Und Impfinstitut Und Institut Zur Erforsch
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