C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 233/65 (2006.01) C07C 271/58 (2006.01) C07C 275/30 (2006.01) C07C 275/64 (2006.01) C07D 213/81 (2006.01)
Patent
CA 2698795
There is provided a process for preparing sorafenib or a salt thereof comprising the use of a compound of formula (A), wherein R' is selected from the group consisting of hydrogen, -C(O)OA, - C(O)CX3, - OH C(O)NH2, -C(O)-NHOH or (a). There is also provided intermediate compounds of general formula (A), N-methyl-4-(4- ureidophenoxy)picolinamide, 4-(2-(methylcar- bamoyl)pyridin-4-yloxy)phenylcarbamate derivative and N-methyl-4-(4-(2,2,2- trihaloacetamido)phenoxy)picolinamide, processes for their preparation and their use in the preparation of sorafenib.
La présente invention concerne un procédé de préparation de sorafénib ou d'un sel de celui-ci, comprenant l'utilisation d'un composé de formule (A), dans laquelle R' est choisi dans le groupe constitué de l'hydrogène, de -C(O)OA, de -C(O)CX3, de -OH C(O)NH2, de -C(O)-NHOH ou de (a). La présente invention concerne également des composés intermédiaires de formule générale (A), de type N-méthyl-4-(4-uréidophénoxy)picolinamide, dérivé du 4-(2-(méthylcarbamoyl)pyridin-4-yloxy)phénylcarbamate et N-méthyl-4-(4-(2,2,2- trihaloacétamido)phénoxy)picolinamide, leurs procédés de préparation et leur utilisation dans le cadre de la préparation du sorafénib.
Chikhalikar Sandip
Ghagare Maruti
Kankan Rajendra Narayanrao
Rao Dharmaraj Ramachandra
Cipla Limited
Sim & Mcburney
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