C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 215/28 (2006.01) C07C 213/00 (2006.01) C07C 213/08 (2006.01) C07C 215/32 (2006.01) C07C 217/58 (2006.01) C07D 209/44 (2006.01) C07D 221/14 (2006.01)
Patent
CA 2192836
A process is disclosed for the preparation of the substantially pure compound of formula (I) comprising catalytic hydrogenation of a compound of formula (II) wherein R6 and R7 are independently selected from (i) wherein Ra and Rb are independently selected from hydrogen, loweralkyl and phenyl and Rc, Rd and Re are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and (ii) wherein the naphthyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or R6 and R7 taken together with the nitrogen atom to which they are bonded are (a) or (b) wherein Rf, Rg, Rh and Ri are independently selected from hydrogen, loweralkyl, alkoxy, halogen and trifluoromethyl; or an acid addition salt thereof.
Procédé de préparation d'un composé pratiquement pur de la formule (I) ou d'un sel d'addition d'acide de celui-ci, comprenant l'hydrogénation catalytique d'un composé de la formule (II) dans laquelle R¿6? et R¿7? sont choisis indépendamment entre le groupe (i) où R¿a? et R¿b? sont choisis indépendamment entre hydrogène, alkyle inférieur et phényle, et R¿c?, R¿d? et R¿e? sont choisis indépendamment entre hydrogène, alkyle inférieur, trifluorométhyle, alcoxy, halo et phényle, et le groupe (ii) où le noyau naphtyle n'est pas substitué ou est substitué par un, deux ou trois substituants choisis indépendamment entre alkyle inférieur, trifluorométhyle, alcoxy et halo; ou bien R¿6? et R¿7? pris ensemble avec l'atome d'azote auquel ils sont liés représentent (a) ou (b) dans lesquels R¿f?, R¿g?, R¿h? et R¿i? sont choisis indépendamment entre hydrogène, alkyle inférieur, alcoxy, halogène et trifluorométhyle.
Goodmonson Owen J.
Haight Anthony R.
Parekh Shyamal I.
Robbins Timothy A.
Seif Louis S.
Abbott Laboratories
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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