Process for the preparation of a tetrapeptide

Details Process for the preparation of a tetrapeptide Process for the preparation of a tetrapeptide

C - Chemistry, Metallurgy

07

K

C07K 5/107 (2006.01) C07K 1/02 (2006.01) C07K 1/06 (2006.01) C07K 5/083 (2006.01) C07K 5/10 (2006.01)

Patent

CA 2323678

The present invention discloses a new and improved process for the preparation of the tetrapeptide H-Tyr-D-Ala-Phe(F)-Phe-NH2 which is a peptide of formula (I) or a pharmaceutically acceptable salt thereof, as well as new intermediates in the preparation thereof. The novel process is suitable for large scale production.

La présente invention concerne un nouveau procédé amélioré de préparation du tétrapeptide H-Tyr-D-Ala-Phe(F)-Phe-NH¿2? qui est un peptide de la formule (I) ou d'un sel de ce peptide acceptable du point de vue pharmaceutique, ainsi que de nouveaux intermédiaires dans la préparation de ce peptide. Le nouveau procédé selon l'invention convient à une production à grande échelle.

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