C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
167/104, 195/39.
C12Q 1/56 (2006.01) C07K 14/745 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1195614
ABSTRACT The present invention provides a process for the production or a tissue thromboplastin prepar- ation which is sensitive towards coagulation Factor VII by the production of an acetone dry powder from mammalian tissues and extraction of the powder with salt solution, wherein the extraction is carried out with a salt solution which contains 1 to 20 mMole/litre of calcium ions and optionally a surface-active agent and the extract obtained is, if desired, dried. The present invention also provides a reagent for assessing blood coagulability with a content of thromboplastin and calcium salt, the thromboplastin having been obtained by the above process. If desired, the reagent can also contain a thrombo- plastin preparation which is insensitive towards Factor VII in an amount such that a predetermined Factor VII sensitivity is present.
417627
Becker Udo
Schaich Eugen
Weigert Manfred
Boehringer Mannheim G.m.b.h.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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