Process for the preparation of acetic acid derivatives

Details Process for the preparation of acetic acid derivatives Process for the preparation of acetic acid derivatives

C - Chemistry, Metallurgy

07

C

260/528.1, 260/5

C07C 53/122 (2006.01) C07C 51/06 (2006.01) C07C 51/08 (2006.01) C07C 51/41 (2006.01) C07C 53/128 (2006.01)

Patent

CA 1077057

ABSTRACT OF THE DISCLOSURE: Process for the preparation of di-n-propyl acetic acid of formula : Image and its non-toxic alkali and alkaline earth metal salts whereby in a single stage, sodium n-propylate in n-propanol medium is added to a reaction medium formed of a cyanacetic ester of general formula : Image in which R represents an alkyl radial having from 1 to 4 carbon atoms, and n-propyl bromide or iodide, the alkylation reaction taking place under reflux, the crude ester obtained is saponified with a 10 to 20% solution of sodium or potassium hydroxide, the salt thus obtained is acidified with a strong acid, to give the crude di-n-propyl cyanacetic acid which is decarboxylated by heating at a temperature between 140 and 190°C, to provide the di-n-propyl acetonitrile, - the di-n-propyl acetonitrile, obtained is hydrolysed by means of an aqueous solution of 75 to 80% sulphuric acid at a temperature of 80-140°C to give the crude di-n-propyl acetamide, which is hydrolysed by means of an aqueous solution of 75-80% sulphuric acid at a temperature of 40-80°C in the presence of sodium nitrite, to provide di-n-propyl acetic acid, which is caused to react, if so desired, with an alkali metal hydroxide or alkaline earth metal oxide in order to obtain the corresponding salt.

278112

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