Process for the preparation of adsorbates of valsartan...

Details Process for the preparation of adsorbates of valsartan... Process for the preparation of adsorbates of valsartan...

A - Human Necessities

61

K

A61K 31/41 (2006.01) A61K 9/20 (2006.01) A61K 47/10 (2006.01) A61K 47/26 (2006.01) A61K 47/36 (2006.01)

Patent

CA 2504551

The present invention relates to a process for the preparation of adsorbates of valsartan and/or its solvates or hydrates wherein one starts with a solution of valsartan or of one of its pharmaceutically acceptable salts and/or their solvates or hydrates in at least one organic solvent where the total water content of the solvent is not higher than 15 % by volume, preferably not higher than 5 % by volume, disperses therein an adsorbing material selected from the group consisting; of celluloses, cellulose derivatives, polyols, sugars, sugar derivatives, maltodextins, cyclodextrins, starches, polydextroses, or their mixtures, and removes the solvent. The invention further relates to valsartan adsorbates that can be prepared with the processes precited, as well as pharmaceutical formulations for the preparation of which the valsartan adsorbates are employed.

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