Process for the preparation of .alpha.-[4-(4-...

Details Process for the preparation of .alpha.-[4-(4-... Process for the preparation of .alpha.-[4-(4-...

C - Chemistry, Metallurgy

07

C

260/514.5

C07C 233/12 (2006.01)

Patent

CA 1124260

ABSTRACT OF THE DISCLOSURE A new process for preparing 2-[4-(4-chlorobenzoylamino- ethyl)-phenoxy]-2-methylpropionic acid of the formula: Image and salts thereof, comprising reacting N-(4-chlorobenzoyl)- tyramine,acetone, chloroform and alkali at a temperature of from about 10 to 40°C., in a molar ratio of N-(4-chloro- benzoyl)-tyramine to acetone to chloroform of 1:20 to 100:2 to 10, and 3 to 4 moles of alkali per mole of chloroform, the compound has lipid- and cholesterol-lowering action the new process is more economic and produces a greater yield.

326593

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