Process for the preparation of .alpha.-aminosubstituted...

C - Chemistry – Metallurgy – 07 – D

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C07D 223/16 (2006.01) C07D 209/40 (2006.01)

Patent

CA 2433089

The invention relates to a process for the preparation of .alpha.- aminosubstituted carboxylic acid amide compounds and/or their salts comprising reacting a carboxylic acid amine of a primary amine with a nitrosylating agent in the presence of a base followed by hydrolysis to give a hydroxy imino derivative followed by hydrogenation and if necessary converting a base or acid of the .alpha.-aminosubstituted carboxylic acid amine into one of its salts.

L'invention concerne un procédé de préparation de composés amides d'acides carboxyliques .alpha.-aminosubstitués et/ou de leurs sels consistant à mettre en réaction une amine d'acide carboxylique d'une amine primaire avec un agent de nitrosylation en présence d'une base, puis à réaliser une hydrolyse afin d'obtenir un dérivé hydroxy imino, suivie d'une hydrogénation, et si nécessaire de la transformation d'une base ou d'un acide de l'amide d'acide carboxylique .alpha.-aminosubstitué en l'un de ses sels.

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