Process for the preparation of alpha-aryl-gamma-butyrolactones

Details Process for the preparation of alpha-aryl-gamma-butyrolactones Process for the preparation of alpha-aryl-gamma-butyrolactones

C - Chemistry, Metallurgy

07

D

C07D 307/33 (2006.01) C07D 315/00 (2006.01) C07D 405/04 (2006.01) C07D 407/04 (2006.01) C07D 409/04 (2006.01)

Patent

CA 2150948

A process for preparing a lactone of general formula (I), where R is an optionally substituted phenyl group or an optionally substituted mono- or bicyclic heteroaryl radical which process comprises reacting an anion of a malonate of formula (II) with an ethylene compound of formula (III) Y-CH2-CH2OZ, to give a compound of formula (IV) and hydrolysing the compound of formula (IV) to give a lactone of formula (I). The lactones are of use as intermediates for preparing 5-HT1A binding agents.

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