Process for the preparation of alpha-l-aspartyl-l-...

Details Process for the preparation of alpha-l-aspartyl-l-... Process for the preparation of alpha-l-aspartyl-l-...

C - Chemistry, Metallurgy

07

K

530/5.06

C07K 5/06 (2006.01) C07K 5/075 (2006.01)

Patent

CA 1298434

PROCESS FOR THE PREPARATION OF .alpha.-L-ASPARTYL-L-PHENYLALANINE METHYL ESTER ABSTRACT An improved regioselective process for the preparation of .alpha.-L-aspartyl-L-phenylalanine methyl ester is disclosed. A controlled aqueous coupling reaction between .beta.-methyl-L-aspartate-N-carboxyanhydride and L- phenylalanine produces the aspartyl methyl ester of .alpha.-L- aspartyl-L-phenylalanine which is subsequently hydrolyzed and selectively esterified without isolation. The hydrochloride salt of .alpha.-L-aspartyl-L-phenylalanine methyl ester, which is selectively precipitated from the esteriication mixture, can be neutralized to .alpha.-L- aspartyl-L-phenylalanine methyl ester, which is intended for use as a sweetening agent for foodstuffs and beverages.

521864

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