Process for the preparation of amino-pyrrolidine derivatives

Details Process for the preparation of amino-pyrrolidine derivatives Process for the preparation of amino-pyrrolidine derivatives

C - Chemistry, Metallurgy

07

D

C07D 207/14 (2006.01)

Patent

CA 2491133

The invention is concerned with a process for the manufacture of 3-amino- pyrrolidine derivatives of the formula (I), wherein R1 signifies hydrogen or an amino protecting group; Z signifies hydrogen or an amino protecting group; and * represents a center of chirality. 3-Amino-pyrrolidine derivatives, especially optically active 3-amino-pyrrolidine derivatives, are intermediates for the production of agrochemicals and of pharmaceutically active substances such as, for example, of vinylpyrrolidinone-cephalosporin derivatives.

L'invention concerne un procédé relatif à l'élaboration de dérivés de 3-amino-pyrrolidine de formule (I). Dans ladite formule, R?1¿ est hydrogène ou un groupe protecteur amino; Z est hydrogène ou un groupe protecteur amino; et * est un centre de chiralité. Les dérivés considérés, en particulier du type optiquement actif, sont des intermédiaires pour l'élaboration de produits agrochimiques et de substances pharmaceutiquement actives, comme les dérivés de vinylpyrrolidinone-céphalosporine, par exemple.

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