Process for the preparation of aminopyrimidines

Details Process for the preparation of aminopyrimidines Process for the preparation of aminopyrimidines

C - Chemistry, Metallurgy

07

D

C07D 239/46 (2006.01) C07D 239/545 (2006.01) C07D 239/58 (2006.01)

Patent

CA 2051338

- 1 - HOE 90/F 274 Abstract of the disclosure Process for the preparation of aminopyrimidines 2-Aminopyrimidines of the formula I Image (I) in which X and Y are O or S and R1 and R2 independently of one another are lower alkyl, alkoxyalkyl or haloalkyl, are obtained by reacting propanediimidates of the formula II R1-X-C(-NH)-CH2-C(=NH)-Y-R2 (II) or salts thereof with cyanamide in the presence of a base at pH values above pH 7. The process allows the aminopyrimidines to be prepared in a one-pot reaction.

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