Process for the preparation of amorphous atorvastatin

Details Process for the preparation of amorphous atorvastatin Process for the preparation of amorphous atorvastatin

C - Chemistry, Metallurgy

07

D

C07D 207/34 (2006.01) A61K 31/40 (2006.01)

Patent

CA 2392025

Atorvastatin, the substance known by the chemical name [R-(R*,R*)]-2-(4- fluorophenyl)-.beta.,.delta.-dihy- droxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1- heptanoic acid hemi calcium salt, is readily available in one of its crystalline forms as it is known from the prior art. The present invention relates to a novel process for preparing atorvastatin in an amorphous form by precipitating the atorvastatin using a solvent of a second type from a solution of atorvastatin which is provided with a solvent of a first type. This process is useful for the conversion of atorvastatin in a crystalline form into atorvastatin in an amorphous form.

L'invention concerne l'atorvastatine, substance connue sous la dénomination chimique de hémi sel de calcium d'acide heptanoïque [R-(R*,R*)]-2-(4-fluorophényl)- beta , delta -dihydroxy-5-(1-méthyléthyl)-3-phényl-4-[(phénylamino)carbonyl]-1H-pyrrole-1, facilement disponible dans une de ses formes cristallines, conformément à l'état de la technique. La présente invention concerne un nouveau procédé de préparation de l'atorvastatine sous une forme amorphe par précipitation de l'atorvastatine à l'aide d'un solvant d'un second type d'une solution d'atorvastatine avec un solvant d'un premier type. Ce procédé sert à convertir l'atorvastatine sous forme cristalline en atorvastatine sous forme amorphe.

Affiliated with

Also associated with

Rating

Process for the preparation of amorphous atorvastatin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of amorphous atorvastatin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of amorphous atorvastatin will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1491904