Process for the preparation of an .alpha.-amino carbonyl...

C - Chemistry – Metallurgy – 07 – C

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C07C 249/02 (2006.01) C07C 231/02 (2006.01) C07C 237/16 (2006.01) C07C 251/08 (2006.01) C07C 251/24 (2006.01) C07C 253/30 (2006.01) C07C 255/28 (2006.01) C07C 255/61 (2006.01)

Patent

CA 2517942

The invention relates to a process for the preparation of an .alpha.-amino carbonyl compound by reacting an imine starting material with a suitable electrophile in the presence of a base. This process has the advantage that the imine starting materials can be prepared from glyoxylic acid esters or glyoxylic acid ester derivatives and .alpha.-hydrogen containing primary amines, which are usually cheap and readily available. These imine starting materials can usually be prepared with a high yield and/or almost without the formation of any side products.

L'invention concerne un procédé de préparation d'un composé .alpha.-amino carbonyle, consistant à faire réagir une imine, comme produit de départ, avec un électrophile approprié, en présence d'une base. Ce procédé offre l'avantage que les imines, en tant que produits de départ, peuvent être préparées à partir des esters d'acide glyoxylique ou des dérivés d'esters d'acide glyoxylique et d'amines primaires contenant un hydrogène .alpha., qui sont généralement d'un coût avantageux et facilement disponibles. Ces imines, en tant que produits de départ, peuvent généralement être préparées avec un haut rendement et/ou quasiment sans formation de produits secondaires.

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