A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/227
A61K 31/475 (2006.01) A61K 47/10 (2006.01) A61K 47/12 (2006.01)
Patent
CA 1319888
A B S T R A C T The invention relates to a process for the preparation of an antipsoriatic pharmaceutical composition containing 17,18-dehydro- apovincaminol 3',4',5'-trimethoxybenzoate or its pharmaceutically acceptable acid addition salts, which comprises dissolving one equivalent of 17,18- dehydroapovincaminol 3',4',5'-trimethoxybenzoate or its pharmaceutically acceptable acid addition salt in 1.1 to 50, preferably 5 to 20, equivalents of an organic acid containing no basic group and being soluble in water or in a water-miscible monovalent or polyvalent alcohol or in a mixture thereof, or in a solution prepared from the organic acid with water or with a water-miscible monovalent or polyvalent alcohol or with a mixture thereof, and a) formulating the solution to a pharmaceutical composition as such or, if desired, together with therapeutically active agents showing no synergism with the active ingredient and/or with pharmaceutical auxiliary materials (additives), or b) diluting the solution with 5 to 50 parts by weight of water and formulating the thus-obtained gel, containing the active ingredient in a homogeneous molecular distribution, as such or together with therapeutically active agents showing no synergism with the active ingredient and/or with a pharmaceutically acceptable auxiliary materials to a pharmaceutical composition.
569123
Barta Nee Bukovecz Margit
Fekete Gyorgy
Forgacs Lilla
Galambos Janos
Hangay Gyorgy
Barta Nee Bukovecz Margit
Fekete Gyorgy
Forgacs Lilla
Galambos Janos
Hangay Gyorgy
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