Process for the preparation of an essentially pure polymorph...

Details Process for the preparation of an essentially pure polymorph... Process for the preparation of an essentially pure polymorph...

C - Chemistry, Metallurgy

07

D

C07D 231/40 (2006.01) A61K 31/4155 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2511325

The invention relates to an improved process for the preparation of a polymorph of 1-[tert-butyl-1-p-tolyl-1H-pyrazol-5-yl]-3-[4-(2-morpolinin-4-yl- ethoxy)naphthalen-1-yl]-urea (1) by crystallization from an alcohol, wherein the improvement is that crude (1) is treated with ethanol.

L'invention concerne un procédé amélioré de préparation d'un polymorphe de 1-[tert-butyl-1-p-tolyl-1H-pyrazol-5-yl]-3-[4-(2-morpolinin-4-yl-éthoxy)naphtalén-1-yl]-urée (1) consistant à effectuer une cristallisation à partir d'un alcool, l'amélioration résidant dans le fait que du pétrole brut (1) est traité au moyen d'éthanol.

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