C - Chemistry – Metallurgy – 08 – B
Patent
C - Chemistry, Metallurgy
08
B
260/220.2
C08B 37/16 (2006.01)
Patent
CA 1207322
ABSTRACT OF THE DISCLOSURE The invention relates to a process for the preparation of inclusion complexes of N-(1-phenylethyl)-3,3-diphenylpropylamine (referred to as phendiline) or its hydrochloride with cyclodextrin, and the inclusion compounds so prepared. The process comprises reacting N-(1-phenylethyl)-3,3-diphenyl- propylamine base or hydrochloride thereof with cyclodextrin (1 mmole related to the base and 1 - 3.0 mmoles related to the hydrochloride) under stirring at 4 - 60°C in aqueous and/or ethanolic medium and optionally reacting the obtained N-(1-phenylethyl)-3,3-diphenylpropylamine cyclodextrin complex with hydrochloric acid to obtain the cyclodextrin complex of the hydrochloride. Phendiline itself is a coronary dilatator calcium antagonist. The disclosed process and complexes improve the water solubility of phendiline thus accelerating and increasing its rate of resorption.
404583
Kiss Pal
Korbonits Dezso
Stadler Agnes
Szejtli Jozsef
Turcsan Istvan
Chinoin Gyogyszer-Es Vegyeszeti Termekek Gyara Rt
Fetherstonhaugh & Co.
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