Process for the preparation of an injectable chondroitin...

Details Process for the preparation of an injectable chondroitin... Process for the preparation of an injectable chondroitin...

C - Chemistry, Metallurgy

08

B

260/219

C08B 37/08 (2006.01) A61K 31/715 (2006.01)

Patent

CA 1207758

ABSTRACT The invention relates to a process for the preparation of an injectable chondroitin polysulfate comprising; A) oxidatively depolymerizing crude chondroitin polysulfate B) if necessary bleaching the depolymerized chondroitin polysulfate with peracetic acid, C) subjecting the thus obtained product once or twice to precipitation with methanol, ultrafiltration or both precipitation with methanol acid ultrafiltration for fractionation in respect of molecular weight, D) if necessary demineralizing the fractionated product with cation exchangers, and E) if necessary, decolorizing the thus obtained product with active charcoal. The invention further relates to a chondroitin polysulfate prepared by the above process, the process of the invention produces chondroitin polysulfate with low toxicity thereby enabling the risk free therapeutic use of these substances in the form of an injection.

402613

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