Process for the preparation of an insulin precursor in...

Details Process for the preparation of an insulin precursor in... Process for the preparation of an insulin precursor in...

C - Chemistry, Metallurgy

12

N

530/15.12, 195/1

C12N 15/62 (2006.01) C07K 14/36 (2006.01) C07K 14/62 (2006.01) C07K 19/00 (2006.01)

Patent

CA 2002062

- 1 - Abstract of the disclosure HOE 88/F 313 K A process fox the preparation of an insulin precursor in Streptomycetes When a gene for a shortened proinsulin in which the insulin B chain is linked to the A chain only via Lys or Lys-Lys is coupled to the tendamistat gene, this gene construction is introduced into an expression vector, and the latter is used to transform a Streptomycetes host cell, there is expression and secretion of the corres- ponding fusion protein. The fusion protein can easily be cleaved to give insulin precursors.

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