Process for the preparation of an intermediate useful in the...

Details Process for the preparation of an intermediate useful in the... Process for the preparation of an intermediate useful in the...

C - Chemistry, Metallurgy

07

C

C07C 237/46 (2006.01) C07C 231/02 (2006.01) C07C 231/12 (2006.01)

Patent

CA 2201012

A process for the preparation of (S)-N,N'-bis[2-hydroxy-1- (hydroxymethyl)ethyl]-5-(2- acetoxy-propionylamino)-2,4,6-triiodo-isophthalamide, an intermediate useful for the synthesis of iopamidol, by reaction between L-5-(2-acetoxy-propionylamino)- 2,4,6-triiiodo- isophthaloyl dichloride and 2-amino-1,3-propanedio in N-methylpyrrolidone and in the presence of a base, is described.

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