Process for the preparation of an oral solid dosage form...

Details Process for the preparation of an oral solid dosage form... Process for the preparation of an oral solid dosage form...

A - Human Necessities

61

K

A61K 47/40 (2006.01) A61K 9/20 (2006.01) A61K 31/195 (2006.01) A61K 31/196 (2006.01) A61K 47/48 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2163111

The invention relates to a novel advantageous process for the preparation of an oral solid dosage form containing diclofenac or a pharmaceutically acceptable salt thereof. The dosage form is obtainable by direct compression of an inclusion compound consisting of diclofenac, or a salt thereof, with .gamma.-cyclodextrin. The inclusion compound itself is novel and is likewise an object of the invention.

L'invention se rapporte à un nouveau procédé avantageux destiné à la préparation d'une forme galénique orale solide contenant du diclofénac, ou un sel pharmaceutiquement acceptable de celui-ci. La forme galénique peut être obtenue par compression directe d'un complexe d'insertion constitué de diclofénac ou d'un sel de celui-ci, avec de la gamma -cyclodextrine. Le complexe d'insertion est lui-même nouveau et constitue également un objet de l'invention.

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