C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
260/208.9
C07F 7/10 (2006.01) C12P 29/00 (2006.01)
Patent
CA 1206960
ABSTRACT OF THE DISCLOSURE The invention relates to a process for the prepa- ration of an oxytetracycline-calcium silicate complex salt from a fermentation broth. According to the invention the complex salt is prepared as follows: the fermentation broth (optionally pre-treated with a surface- active substance) a) after an optional pretreatment by a water-soluble silicate is acidified to a pH-value of 0.5 - 3.0, then filtered off the mycelium - optionally using a filter aid - the pH-value of the filtrate is adjusted to 4-5 by a lye and after the addition of a calcium salt or in the presence of calcium ions a water-soluble silicate and optionally a water-soluble carbonate or hydrogen carbonate is added and after longer stirring the formed oxytetracycline-calcium silicate complex salt is filtered off optionally in the presence of a filter aid, or b) is admixed with a calcium salt and a water-soluble silicate, if necessary the pH-value is adjusted to 8 to 11 by a lye, optionally a water-soluble carbonate or hydrogen carbonate is added to the mixture and after longer stirring the oxytetracycline-calcium silicate complex salt precipitated onto the mycelium is filtered off optionally in the presence of a filter aid and the complex salt obtained according to a) or b) dried at a temperature of 20 to 120°C. By the process according to the invention the valuable antibiotic oxytetracycline may be separated from the fermentation broth in an easy manner. The complex obtained according to a) contains up to 50 % of antibiotic and is suitable for the processing in the pharmaceutical industry while the product according to b) contains 10 to 20% of antibiotic and may be used as fodder additive directly.
439871
Balint Janos
Cseke Laszlo
Fabian Ferenc
Kun Lajos
Szarvas Miklos
Biogal Gyogyszergyar Rt
Marks & Clerk
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