Process for the preparation of an (rp)-8-substituted camps

Details Process for the preparation of an (rp)-8-substituted camps Process for the preparation of an (rp)-8-substituted camps

C - Chemistry, Metallurgy

07

H

C07H 19/20 (2006.01) A61K 31/7076 (2006.01)

Patent

CA 2662565

This invention relates to a process for the preparation of an (Rp)-8-substituted adenosine-3',5'-cyclic phosphorothioic acid, or a salt or ester thereof, which comprises P-amidating 8-bromoadenosine-3',5'-cyclic phosphoric acid, and reacting the P-amidate with a base and with carbon disulphide to yield (Rp)-8-bromoadenosine-3',5'-cyclic phosphorothioic acid or a salt or ester thereof.

L'invention porte sur un procédé de préparation d'un acide phosphorothioique (Rp)-8-substitué adénosine-3',5'-cyclique, ou d'un sel ou un ester de ce dernier, procédé selon lequel on effectue la P-amidation d'un acide phosphorique 8-bromoadénosine-3',5'-cyclique, et on fait réagir le P-amidate avec une base et avec du disulfure de carbone afin d'obtenir un acide phosphorothioique (Rp)-8-bromoadénosine-3',5'-cyclique, ou un sel ou un ester de ce dernier.

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