Process for the preparation of anagrelide and analogues

Details Process for the preparation of anagrelide and analogues Process for the preparation of anagrelide and analogues

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) C07C 309/66 (2006.01)

Patent

CA 2746145

The present invention relates to a novel process for producing quinazoline compounds which are useful in therapy. More specifically, the compounds produced by the process of the invention are useful in the treatment of a number of cardiovascular diseases. The process of the invention provides 6,7-dichloro-1,5- dihydroimidazo [2,1-b] quinazolin 2 (3H)-one, more commonly known as anagrelide and its analogues in a clean and efficient manner.

La présente invention porte sur un nouveau procédé de production de composés quinazolines qui sont utiles en thérapie. Plus spécifiquement, les composés obtenus par le procédé de l'invention sont utiles dans le traitement d'un certain nombre de maladies cardiovasculaires. Le procédé de l'invention permet d'obtenir de la 6,7-dichloro-1,5-dihydroimidazo[2,1-b]quinazolin-2-(3H)-one, plus couramment connue sous le nom d'anagrélide, et ses analogues d'une façon propre et efficace.

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