Process for the preparation of aqueous mixed micelle solutions

Details Process for the preparation of aqueous mixed micelle solutions Process for the preparation of aqueous mixed micelle solutions

A - Human Necessities

61

K

167/163

A61K 9/10 (2006.01) A61K 9/107 (2006.01)

Patent

CA 2009307

ABSTRACT OF THE DISCLOSURE A process for the preparation of aqueous mixed micelle solutions containing mixed micelles formed from lipoids and salts of bile acids wherein active agents which are sparingly soluble or insoluble in water are optionally solubilized, characterized by suspending the free bile acids at a temperature of 40°C to 100°C in an aqueous solution containing, if desired, isotonizing additives and/or water-soluble active agents, dispersing the lipoids at a temperature of 40°C to 100°C in this suspension, and neutralizing the resultant dispersion with bases at a temperature of 0°C to 100°C, with the proviso that optionally the active agents sparingly soluble or insoluble in water are dispersed together with the lipoids or are solubilized in the mixed micelle solution which does not contain these active agents.

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