Process for the preparation of aromatically substituted...

Details Process for the preparation of aromatically substituted... Process for the preparation of aromatically substituted...

C - Chemistry, Metallurgy

12

P

195/134.1

C12P 13/22 (2006.01) C07B 55/00 (2006.01) C12P 41/00 (2006.01)

Patent

CA 1265083

HOE 84/F 248 Abstract of the disclosure Aromatically substituted L-amino acids are ob- tained particularly advantageously by enzymatic cleavage of the racemate of the lower alkyl esters using.alpha.-chymo- trypsin, extraction of the D-ester from the basified reac- tion mixture using an organic solvent, racemization, ex- traction of the D,L-ester using an aqueous acid, and re- turn, after concentration, to the process, and isolation of the L-amino acid from the alkaline residue from extrac- tion after acidification. The enzyme is advantageously immobilized on an inorganic carrier. The racemization is advantageously carried out on the extract, that is to say without isolation of the D-ester.

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