Process for the preparation of arylacetic acid derivatives

Details Process for the preparation of arylacetic acid derivatives Process for the preparation of arylacetic acid derivatives

C - Chemistry, Metallurgy

07

C

260/514, 260/329

C07C 57/30 (2006.01) C07C 37/055 (2006.01) C07C 41/32 (2006.01) C07C 43/215 (2006.01) C07C 43/295 (2006.01) C07C 45/67 (2006.01) C07C 45/71 (2006.01) C07C 51/377 (2006.01) C07C 59/42 (2006.01) C07C 309/66 (2006.01) C07C 309/73 (2006.01) C07D 333/24 (2006.01)

Patent

CA 1122603

ABSTRACT OF THE DISCLOSURE The invention relates to the preparation of arylacetic acid com- pounds of formula I Image I wherein R1 is hydrogen, methyl or ethyl, R2 is hydrogen, fluorine or an alkyl having from 1 to 4 carbon atoms, and R3 is hydrogen, phenyl, alkoxy having from 1 to 6 carbon atoms, phenoxy, benzoyl which is unsubstituted or is sub- stituted by a substituent which does not interfere with the course of reac- tion or thenoyl, or R2 and R3 together with the phenyl group they are attached to form a naphthyl group, optionally substituted with one or more alkyl and/or alkoxy groups having from 1 to 4 carbon atoms. The compounds are obtained by subjecting to catalytic hydrogenation arylacetic acids sub- stituted in the 2-position of the arylradical by a group R10O, wherein R10 is phenylamino-carbonyl, 1-phenyl-5-tetrazolyl, 2-benzoxazolyl or a group -SO2Me, wherein Me is a metal atom preferably a sodium or potassium atom, or a group -SO2R6, in which R6 is alkyl having from 1 to 4 carbon atoms, 4- methyl-phenyl-, amino, acylamino, alkoxycarbonylamino having from 1 to 4 carbon atoms in the alkyl moiety or a group R7-N=C-NH-R7 in which R7 is alkyl having from 1 to 4 carbon atoms, cycloalkyl having 5 to 6 carbon atoms or tolyl. It is known that many of the compounds of formula I have valuable antirheumatic and antiinflammatory properties and small side effects.

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