Process for the preparation of atomoxetine hydrochloride

Details Process for the preparation of atomoxetine hydrochloride Process for the preparation of atomoxetine hydrochloride

C - Chemistry, Metallurgy

07

C

C07C 213/06 (2006.01) C07C 213/10 (2006.01) C07C 217/48 (2006.01)

Patent

CA 2560899

The present invention provides improved processes for the preparation of atomoxetine hydrochloride under reaction conditions that improve reaction yields and facilitate commercial synthesis. In particular, the invention is directed to the synthesis of atomoxetine HC1 by adding HCl to a mixture of (R)- (-)-tomoxetine (S)-(+)~mandelate with an organic solvent, with or without a base and water.

La présente invention concerne des procédés améliorés de fabrication d'hydrochlorure d'atomoxétine dans des conditions de réaction qui 'améliorent les rendements de la réaction et facilitent la synthèse commerciale. L'invention concerne en particulier la synthèse d'atomoxétine HC1 pasr adjonction de HCl à un mélange de (R)-(-)-tomoxétine (S)-(+)-mandelate avec un solvant organique, avec ou sans une base et de l'eau.

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