Process for the preparation of basic esters of substituted...

C - Chemistry – Metallurgy – 07 – C

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C07C 69/76 (2006.01) A61K 31/235 (2006.01) C07C 35/00 (2006.01) C07C 67/475 (2006.01) C07C 69/74 (2006.01) C07C 69/75 (2006.01) C07C 213/08 (2006.01) C07C 219/12 (2006.01) A61K 31/215 (2006.01)

Patent

CA 1146174

ABSTRACT OF THE DISCLOSURE The yield of compounds having the general formula: Image (I) wherein R represents Image . or Image in the process comprising reacting a substituted hydroxy- cyclohexanecarboxylic acid with an aminoisopropyl chloride is highly improved by heating the reaction mixture to 160 to 240°C for at least 3 hours, and distilling the resulting product under reduced pressure. This process enables the content of the undesired isomer to be reduced to less than 1-1.5%.

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