Process for the preparation of basically substituted...

Details Process for the preparation of basically substituted... Process for the preparation of basically substituted...

B - Operations, Transporting

01

J

260/559.5

B01J 31/02 (2006.01)

Patent

CA 1235430

A B S T R A C T A simplified process for the preparation of basically substituted phenylacetonitriles, in particular of verapamil, is described. This process is carried out with fewer stages and higher yields than the know processes according to the state of the art. A halogen compound such as an alkyl-veratryl chloride is initially reacted with a metal cyanide, whereafter the resulting product is reacted with a Beta-substituted propioni- trile, and the resulting product thus obtained is reduced in the presence of a phenylethylamine to obtain the product, which may optionally be converted into a salt by reaction with an acid.

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