Process for the preparation of benazepril

Details Process for the preparation of benazepril Process for the preparation of benazepril

C - Chemistry, Metallurgy

07

D

C07D 223/16 (2006.01) A61K 31/55 (2006.01) C07C 303/28 (2006.01) C07C 309/65 (2006.01)

Patent

CA 2442573

The present invention relates to an improved process for the preparation of trifluoromethanesulfonic ester of ethyl (R)-2-hydroxy-4-phenylbutyrate, referred to here as triflate in structural Formula I, and to the use of this compound as intermediate for the preparation of ACE (Angiotensin Converting Enzyme) inhibitor, benazepril.

La présente invention se rapporte à un procédé perfectionné de préparation de l'ester trifluorométhanesulfonique du (R)-2-hydroxy-4-phénylbutyrate d'éthyle, désigné comme triflate dans le descriptif et représenté par la formule (I) développée suivante. L'invention se rapporte également à l'utilisation de ce composé en tant qu'intermédiaire pour la préparation d'un inhibiteur de l'enzyme de conversion de l'angiotensine (ACE), le benazépril.

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