Process for the preparation of benzodiazepine derivatives

Details Process for the preparation of benzodiazepine derivatives Process for the preparation of benzodiazepine derivatives

C - Chemistry, Metallurgy

07

D

260/239.1

C07D 498/08 (2006.01) C07D 498/04 (2006.01)

Patent

CA 1041499

TRICYCLIC BENZODIAZEPINES Abstract of the Disclosure Tricyclic benzodiazepine derivatives ("A") bearing a hetero- cyclic ring joined between positions 4 and 5 of the benzodiazepine moiety are described. The heterocyclic ring will contain the nitrogen atom appearing at position 4 of the benzodiazepine ring as well as the hetero atom, which may be either oxygen or nitro- gen, attached to the carbon atom at the 5-position of the benzo- diazepine ring. "A" bearing an oxygen atom in the new hetero- cyclic ring may be formed from the corresponding 4,5-unsaturated benzodiazepines by treatment with an epoxide compound in the presence of an acid catalyst. "A" bearing either a nitrogen or an oxygen atom in the new heterocyclic ring may be prepared by cyclization of the corresponding open compound. "A" are useful as sedative, muscle relaxant and anti-convulsant agents.

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