Process for the preparation of benzoyl ureas

Details Process for the preparation of benzoyl ureas Process for the preparation of benzoyl ureas

C - Chemistry, Metallurgy

07

D

260/363.3, 260/3

C07D 333/62 (2006.01) C07C 275/54 (2006.01) C07D 307/78 (2006.01)

Patent

CA 1265150

NOVEL PROCESS FOR THE PREPARATION OF BENZOYL UREAS Abstract of the Invention A novel process for the preparation of benzoyl ureas is provided wherein the condensed intermediate formed by the reaction of a halogen-substituted nitrobenzene with a hydroxy substituted cyclic or bicylic compound is contacted with water, forming a solid or semi-solid which is easily isolated. Reduction of the nitro compound to the corresponding amine and subsequent carbamoylation of the amine with an isocyanate are all conducted in the same solvent. D-13629

450336

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