Process for the preparation of beta-butyrolactams

Details Process for the preparation of beta-butyrolactams Process for the preparation of beta-butyrolactams

C - Chemistry, Metallurgy

07

D

260/324

C07D 207/26 (2006.01) C07D 207/273 (2006.01) C07D 207/28 (2006.01)

Patent

CA 1279650

ABSTRACT OF THE DISCLOSURE A process for the preparation of a C(3)-C(4)-+ transconfigurated ?-butyrolactam of the formula (I) (I) Image in which R1 represents hydrogen or alkyl, aryl or aralkyl with in each case up to 10 carbon atoms anc R2 and R3 are identical or different and represent hydrogen, alkyl, aryl, aralkyl, alkoxy, aryloxy or aralkoxy with in each case up to 10 carbon atoms, acyl with up to 18 carbon atoms, trifluoromethyl, trifluoromethoxy, nitro, hydroxyl, halogen, amino, carboxyl, sulpha, dialkylamino with up to 4 carbon atoms in the alkyl groups or acylamino with up to 18 carbon atoms, in the form of their isomers, isomer mixtures, racemates or optical antipodes, comprising oxidizing a compound of the formula (II) Image (II) in which R1, R2 and R3 have the above-mentioned meanings, in an inert organic solvent in the presence of a base. Such ?-butyrolactams have an antiamnesic activity.

520592

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