C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/295, 260/329
C07D 333/04 (2006.01) C07C 209/68 (2006.01) C07D 213/38 (2006.01) C07D 307/52 (2006.01) C07D 333/20 (2006.01) C07D 333/28 (2006.01) C07F 9/24 (2006.01) C07F 9/40 (2006.01) C07F 9/58 (2006.01) C07F 9/655 (2006.01) C07F 9/6553 (2006.01)
Patent
CA 1184918
ABSTRACT The present invention provides a process for the preparation of .beta.-cyclo-substituted ethylamines of the general formula:- Ar - CH2 - CH2 - NH2 (I) in which Ar is a heterocyclic or non-heterocyclic aromatic radical, which is optionally mono- or poly- substituted, wherein a compound of the general formula:- Image (II) in which X and Y, which may be the same or different, are alkyl, aryl, al?oxy, aryloxy, dialkylamino or diarylamino radicals, is condensed with a carbonyl compound of the general formula:- Ar - CHO (III) in which Ar is as defined above, to give a compound of the general formula:- Image (IV) in which X, Y and Ar are as defined above, which is treated with a base of the general formula B?M? to give 2 carbanion of the general formula:- Image (V) in which the symbols have the same meanings as above, which is converted by the action of heat int? a derivative of the general formula: Image (VI) in which the symbols have the same meanings same above, which, after taking up in water, gives a compound of the general formula:- Image (VII) in which the symbols have the same meanings as above, which is treated with a reducing agent to give a com- pound of the general formula:- Image (VIII) in which the symbols have the same meanings as above which is reacted with an acid to give a compound of general formula (I).
406278
Chekroun Isaac
Heymes Alain
Ridout & Maybee Llp
Sanofi
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