C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/38 (2006.01) C07F 9/58 (2006.01) C07F 9/6506 (2006.01)
Patent
CA 2668783
A process for the preparation of biphosphonic acids and pharmaceutical acceptable salts thereof, comprises reacting a carboxylic acid with phosphorous trichloride and phosphorous acid in the presence of an aprotic polar solvent. Formula (I):
La présente invention concerne un procédé de préparation des acides biphosphoniques et de leurs sels pharmaceutiques acceptables, ledit procédé comprenant la réaction d'un acide carboxylique avec un trichlorure de phosphore et un acide phosphoreux en présence d'un solvant polaire aprotique. Formule (I) :
Baptista Joana
Mendes Zita
Hovione Inter Limited
Tessier Louis
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