Process for the preparation of bis-indolic compounds

Details Process for the preparation of bis-indolic compounds Process for the preparation of bis-indolic compounds

C - Chemistry, Metallurgy

07

D

260/237.3

C07D 519/04 (2006.01)

Patent

CA 1132544

ABSTRACT OF THE DISCLOSURE A new process is disclosed for the prepar- ation of bis-indolic compounds. The compounds are made from natural alkaloids such as vinblastine or vincristine wherein a number of species having anti- tumoral properties can be isolated, Two compounds are reacted together in the presence of an immonium ion forming reagent to obtain an immonium ion to reduce the first compound and isolate the compound having the anti-tumoral properties. The new compound has the configuration of natural alkaloids, character- ized in that it arises from the reaction of vindoline, desacetyl vindoline. dihydro-14, 15-vindoline, vindorosine or dihydro-2, 16-Na-methyl-methoxy-11 tabersonine with coronaridine, catharanthine, allocatharanthine, dihydro- catharanthine, dihydro-allocatharanthine, voacangine, isoracangine, or conopharyngine.

243046

Affiliated with

Also associated with

Rating

Process for the preparation of bis-indolic compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of bis-indolic compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of bis-indolic compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1088913