Process for the preparation of caprolactam cgrp antagonist...

Details Process for the preparation of caprolactam cgrp antagonist... Process for the preparation of caprolactam cgrp antagonist...

C - Chemistry, Metallurgy

07

D

C07D 223/10 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2647683

An efficient syntheses for the preparation of (3R,6S)-3-amino-6-(2,3- difluorophenyl)-1-(2,2,2-trifluoroethyl)azepan-2-one. The process uses a crystallization driven asymmetric transformation to set the amine stereocenter followed by a cis-selective hydrogenation and epimerization to set the benzylic stereocenter and trans geometry.

Cette invention concerne des synthèses efficaces servant à la préparation de (3R,6S)-3-amino-6-(2,3-difluorophényl)-1-(2,2,2-trifluoroéthyl)azépan-2-one.

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