Process for the preparation of carvedilol and its enantiomers

Details Process for the preparation of carvedilol and its enantiomers Process for the preparation of carvedilol and its enantiomers

C - Chemistry, Metallurgy

07

D

C07D 209/88 (2006.01) A61K 31/403 (2006.01) A61P 9/04 (2006.01) A61P 9/12 (2006.01)

Patent

CA 2589699

The present invention relates to a process for the preparation of carvedilol as well as of the optically active R and S enantiomers thereof and of mixtures of these enantiomers and, more particularly, relates to an improved process for the preparation of carvedilol and its enantiomers characterized by the use of ethyl acetate as reaction solvent.

L'invention concerne un procédé de préparation de carvedilol, ainsi que de ses énantiomères R et S optiquement actifs et des mélanges de ces énantiomères. Plus particulièrement, l'invention concerne un procédé amélioré de préparation de carvedilol et de ses énantiomères, procédé caractérisé par l'utilisation d'acétate d'éthyle comme solvant de réaction.

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