Process for the preparation of castanospermine esters

Details Process for the preparation of castanospermine esters Process for the preparation of castanospermine esters

C - Chemistry, Metallurgy

12

P

195/86

C12P 17/12 (2006.01) C07D 211/46 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2022576

1-Esters of castanospermine have been prepared enzymatically from appropriate activated esters using subtilisin. The esters obtained in this way can be further reacted enzymatically to give diesters which can, in turn, be selectively hydrolyzed to give monoesters in good yield.

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