C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 69/732 (2006.01) C07C 51/377 (2006.01) C07C 67/31 (2006.01) C07C 319/18 (2006.01) C07C 319/20 (2006.01) C12P 13/00 (2006.01) C07C 323/22 (2006.01) C07C 323/52 (2006.01) C07C 323/60 (2006.01)
Patent
CA 2411218
A process for the preparation of chiral a-hydroxycarboxylic acids of the formula Image in which R1 is a C1-C2-alkyl radical optionally substituted by halogen atoms and R2 is a C2-C3-alkyl radical optionally substituted by halogen atoms, from a compound of the formula Image in which R1 is as defined above, R2' is a C2-C3-alkylene radical optionally substituted by halogen atoms, m is 0 or 1 and R is an optionally substituted alkyl radical, an aryl radical, heteroaryl radical or a heterocyclyl radical and X can be oxygen, sulfur, sulfinyl, sulfonyl, imino, C1-C6-alkylimino, xanthate, silyl, or, if m is equal to 0, halogen, which is reacted in the presence of a cyanide group donor to give the corresponding (R)- or (S)-cyanohydrin or its racemate of the formula Image then is converted by means of acidic hydrolysis into an acid of the formula Image or its racemate, and by cleavage of the group of the formula (R)m-X (V), where a resolution is optionally first carried out, the desired chiral a-hydroxycarboxylic acid of the formula (f) is obtained.
Mayrhofer Herbert
Neuhofer Rudolf
Poechlauer Peter
Skranc Wolfgang
Wirth Irma
Dsm Fine Chemicals Austria Gmbh
Riches Mckenzie & Herbert Llp
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