C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 209/52 (2006.01) B01J 31/24 (2006.01) C07D 241/00 (2006.01) C07D 249/00 (2006.01) C07D 487/04 (2006.01) C07F 17/02 (2006.01)
Patent
CA 2518435
The present invention relates to a process for the efficient preparation of enantiomerically enriched beta amino acid derivatives which are useful in the asymmetric synthesis of biologically active molecules. The process comprises an enantioselective hydrogenation of a prochiral beta amino acrylic acid derivative substrate in the presence of a transition metal precursor complexed with a chiral ferrocenyl diphosphine ligand.
La présente invention concerne un procédé pour préparer efficacement des dérivés d'acide aminé béta enrichis en énantiomères, utilisés dans la synthèse asymétrique de molécules biologiquement actives. Ce procédé consiste en une hydrogénation énantiosélective d'un substrat de dérivé d'acide aminoacrylique béta prochiral en présence d'un précurseur de métal de transition complexé avec un ligand de diphosphine de ferrocényle chiral.
Armstrong Joseph D. III
Krska Shane W.
Njolito Eugenia
Rivera Nelo R.
Rosner Thorsten
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
LandOfFree
Process for the preparation of chiral beta amino acid... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for the preparation of chiral beta amino acid..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of chiral beta amino acid... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1461144