Process for the preparation of chroman derivatives

C - Chemistry – Metallurgy – 07 – D

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C07D 311/72 (2006.01) C07D 311/58 (2006.01) C07D 311/70 (2006.01) C07D 405/00 (2006.01) C07D 407/00 (2006.01) C07D 409/00 (2006.01)

Patent

CA 2253141

Chroman derivatives of the general formula: Image ( C) in which R1 is hydrogen or C1-4-alkyl; R2 is C1-6-alkyl, C3-6-cycloalkyl, optionally substituted aryl or optionally substituted aryl-C1-6-alkyl; R3, R5 and R6 independently of one another are hydrogen, halogen, C1-4-alkyl or optionally substituted aryl; and R4 is C1-6-alkyl, C3-6-cycloalkyl, (C1-6-alkoxy)methyl, optionally substituted aryl, optionally substituted aryl-C1-6-alkyl, C1-6-alkanoyl or optionally substituted aroyl, are obtained from hydroquinone derivatives and alkenes in the presence of Lewis acids. The chroman derivatives (I) are intermediates in the synthesis of pharmaceutically active substances, for example hypolipidemics.

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