Process for the preparation of cimetidine

Details Process for the preparation of cimetidine Process for the preparation of cimetidine

C - Chemistry, Metallurgy

07

D

260/314

C07D 233/90 (2006.01) C07C 323/44 (2006.01) C07D 233/54 (2006.01)

Patent

CA 1164876

ABSTRACT Process for the preparation of cimetidine, wherein N-cyano-N'-methyl-N"-(2-mercaptoethyl)guanidine is reacted with 4-halomethyl-5-methyl-lH-imidazole in water or in a water-containing medium at the pH-range of 8.0 to 9.5. Pure cimetidine crystallizes from the reaction mixture immediately without any particular operations with a yield higher than 70 %.

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