Process for the preparation of citalopram and escitalopram

Details Process for the preparation of citalopram and escitalopram Process for the preparation of citalopram and escitalopram

C - Chemistry, Metallurgy

07

D

C07D 307/87 (2006.01)

Patent

CA 2581195

A process is described for the preparation of citalopram (I) and of the active enantiomer thereof, escitalopram (II), which process comprises the cyclisation reaction of the corresponding precursor diol of the formula III or, respectively, IV in the presence of an azodicarboxylate, a phosphine and a strong base.

L'invention concerne un procédé d'élaboration de citaloprame (I) et de son enantiomère actif, l'escitaloprame (II), comme suit : réaction de cyclisation du diol précurseur correspondant de formule III ou, respectivement, IV en présence d'azodicarboxylate, de phosphine et d'une base forte.

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