Process for the preparation of clausenamide

Details Process for the preparation of clausenamide Process for the preparation of clausenamide

C - Chemistry, Metallurgy

07

D

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C07D 207/267 (2006.01) C07D 207/26 (2006.01) C07D 207/273 (2006.01) C07D 207/28 (2006.01)

Patent

CA 1280427

ABSTRACT OF THE DISCLOSURE A new synthetic route to clausenamide having the formula Image has been found. It has been found that a compound of the formula Image can be oxidized to provide the stereochemically correctly configured product, clausenamide. A number of new compounds useful in the total synthesis of clausenamide have also been found. These compounds have the general formula Image wherein R is ?-C6H5, CHO, ?-C6H5 and CH20. Clausenamide shows an antiamnesic action and an action affording protection from cerebral hypoxia in animal experiments.

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