C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 495/04 (2006.01)
Patent
CA 2725997
The present invention relates to a process for the preparation of clopidogrel and, more particularly, to an improved process for the preparation of clopidogrel hydrogen sulfate crystalline Form I by addition of dilute sulfuric acid to a solution of clopidogrel free base in butyl acetate.
La présente invention concerne un procédé pour la préparation de clopidogrel et, plus particulièrement, un procédé amélioré pour la préparation de forme cristalline I dhydrogénosulfate de clopidogrel par ajout dacide sulfurique dilué à une solution de clopidogrel base libre dans lacétate de butyle.
Brescello Roberto
Cotarca Livius
Soriato Giorgio
Urbani Daniele
Riches Mckenzie & Herbert Llp
Zach System S.p.a.
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