C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/12 (2006.01) A61K 31/5377 (2006.01)
Patent
CA 2686267
The invention relates to compositions comprising 2-(5-(4-(2- morpholinoethoxy)phenyl)pyridin-2-yl)--V- benzylacetamide and its mesylate and dihydrochloride salts. More specifically, the invention provides an efficient process for the synthesis of 2-(5- < 4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-AA benzylacetainide and its mesylate and dihydrochloride salts and methods for modulating one or more components of a kinase cascade using the compositions of the invention.
L'invention concerne des compositions comprenant du 2-(5-(4-(2-morpholinoéthoxy)phényl)pyridin-2-yl)-V-benzylacétamide et ses sels de mésylate et de dichlorhydrate. Plus spécifiquement, l'invention fournit un procédé efficace pour la synthèse de 2-(5-(4-(2-morpholinoéthoxy)phényl)pyridin-2-yl)-V-benzylacétamide et ses sels de mésylate et de dichlorhydrate, et des procédés pour moduler un ou plusieurs composants d'une cascade de kinases en utilisant les compositions de l'invention.
Cody Jeremy A.
Coughlin Daniel
Gale Jonathan
Hangauer David G. Jr.
Isbester Paul K.
Kinex Pharmaceuticals Llc
Ridout & Maybee Llp
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