Process for the preparation of compositions for modulating a...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 413/12 (2006.01) A61K 31/5377 (2006.01)

Patent

CA 2686267

The invention relates to compositions comprising 2-(5-(4-(2- morpholinoethoxy)phenyl)pyridin-2-yl)--V- benzylacetamide and its mesylate and dihydrochloride salts. More specifically, the invention provides an efficient process for the synthesis of 2-(5- < 4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-AA benzylacetainide and its mesylate and dihydrochloride salts and methods for modulating one or more components of a kinase cascade using the compositions of the invention.

L'invention concerne des compositions comprenant du 2-(5-(4-(2-morpholinoéthoxy)phényl)pyridin-2-yl)-V-benzylacétamide et ses sels de mésylate et de dichlorhydrate. Plus spécifiquement, l'invention fournit un procédé efficace pour la synthèse de 2-(5-(4-(2-morpholinoéthoxy)phényl)pyridin-2-yl)-V-benzylacétamide et ses sels de mésylate et de dichlorhydrate, et des procédés pour moduler un ou plusieurs composants d'une cascade de kinases en utilisant les compositions de l'invention.

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